{"id":2337,"date":"2024-10-15T18:01:07","date_gmt":"2024-10-15T10:01:07","guid":{"rendered":"https:\/\/www.jiansuoke.com\/post\/?p=2337"},"modified":"2024-10-15T18:01:07","modified_gmt":"2024-10-15T10:01:07","slug":"entrez-db","status":"publish","type":"post","link":"https:\/\/www.jiansuoke.com\/post\/entrez-db.html","title":{"rendered":"Entrez\u5206\u5b50\u5e8f\u5217\u6570\u636e\u5e93\u7cfb\u7edf\u7b80\u4ecb"},"content":{"rendered":"<p>Entrez\u5206\u5b50\u5e8f\u5217\u6570\u636e\u5e93\u7cfb\u7edf(Entrez Molecular Sequence Database System)\u662f\u4e00\u4e2a\u96c6\u6210\u578b\u7684\u68c0\u7d22\u754c\u9762\uff0c\u7f51\u5740\u4e3a\uff1ahttps:\/\/www.ncbi.nlm.nih.gov\/search\/\uff0c\u7531\u7f8e\u56fd\u56fd\u5bb6\u751f\u533b\u4fe1\u606f\u4e2d\u5fc3(National Center for Biotechnology Information, NCBI)\u5efa\u7f6e\uff0c\u5728\u6b64\u754c\u9762\u53ef\u641c\u7d22\u52306\u5927\u7c7b37\u79cd\u6570\u636e\u5e93\u7684\u6570\u636e\uff0c\u7528\u6237\u53ef\u4f9d\u68c0\u7d22\u7ed3\u679c\u76f4\u63a5\u8fde\u5230\u7279\u5b9a\u6570\u636e\u5e93\u505a\u66f4\u6df1\u5165\u7684\u68c0\u7d22\u3002\u672c\u6587\u9488\u5bf9\u4e0a\u8ff0\u6570\u636e\u5e93\u7b80\u4ecb\u5982\u4e0b\uff1a<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-large wp-image-21330\" src=\"https:\/\/www.jiansuoke.com\/post\/wp-content\/uploads\/2024\/09\/20240912111806-66e2cdeec6607.jpg\" alt=\"\" width=\"640\" height=\"106\" \/><\/p>\n<p>Literature (\u6587\u732e\u7c7b\u6570\u636e\u5e93)<br \/>\nGenes (\u57fa\u56e0\u76f8\u5173\u6570\u636e\u5e93)<br \/>\nGenetics (\u9057\u4f20\u5b66\u76f8\u5173\u6570\u636e\u5e93)<br \/>\nProteins (\u86cb\u767d\u8d28\u76f8\u5173\u6570\u636e\u5e93)<br \/>\nGenomes(\u57fa\u56e0\u7ec4\u76f8\u5173\u6570\u636e\u5e93)<br \/>\nChemicals (\u5316\u5b66\u76f8\u5173\u6570\u636e\u5e93)<\/p>\n<p>&nbsp;<\/p>\n<p><strong><a id=\"a2\"><\/a>Literature<\/strong><strong> (<\/strong><strong>\u6587\u732e\u7c7b\u6570\u636e\u5e93)<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Bookshelf<\/strong><\/a><\/p>\n<p>Bookshelf\u5728\u7ebf\u6570\u636e\u5e93\u6536\u5f55\u8d85\u8fc71000\u79cd\u7531NCBI\u6240\u64b0\u5199\u6216\u5217\u7ba1\u4e4b\u751f\u7269\u3001\u533b\u5b66\u4ee5\u53ca\u751f\u547d\u79d1\u5b66\u76f8\u5173\u4e4b\u56fe\u4e66\u3001\u62a5\u544a\u3001\u4ee5\u53ca\u5176\u4ed6\u5f62\u5f0f\u7684\u5b66\u672f\u6587\u732e\u3002<br \/>\n\u672c\u6570\u636e\u5e93\u505a\u4e3aNLM Literature Archive (LitArch)\u7684\u56fe\u4e66\u7c7b\u5168\u6587\u6570\u4f4d\u5bc4\u5b58(digital repository)\u7cfb\u7edf\uff0c\u9664\u4e86\u81f4\u529b\u4e8e\u4fdd\u5b58\u5e76\u7ef4\u6301\u751f\u533b\u9886\u57df\u7535\u5b50\u5168\u6587\u7684\u514d\u8d39\u53d6\u7528\uff0c\u540c\u65f6\u901a\u8fc7\u4e0e\u5176\u4ed6NCBI\u8d44\u6e90\u7684\u96c6\u6210\uff0c\u5982PubMed\u3001Gene\u3001OMIN\u3001\u4ee5\u53caPubChem\uff0c\u8ba9\u7528\u6237\u53ef\u94fe\u63a5\u5230Bookshelf\uff0c\u589e\u52a0\u63a2\u7d22\u7684\u673a\u4f1a\u3002\u7528\u6237\u53ef\u4ee5\u68c0\u7d22\u5230\u56fe\u4e66\u7684\u7bc7\u7ae0\u53ca\u5168\u6587\uff0c\u901a\u8fc7\u68c0\u7d22\u4e0e\u6d4f\u89c8\u529f\u80fd\uff0c\u53ef\u5229\u7528\u5173\u952e\u5b57\u68c0\u7d22\u6216\u6d4f\u89c8\u76f8\u5173\u4e3b\u9898\u4e4b\u56fe\u4e66\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/mesh\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>MeSH<\/strong><\/a><\/p>\n<p>MeSH (Medical Subject Headings)\u662f\u7528\u6765\u7d22\u5f15PubMed\u4e2d\u671f\u520a\u6587\u732e\u7684\u56fd\u5bb6\u533b\u5b66\u56fe\u4e66\u9986\u63a7\u5236\u8bcd\u6c47\u7d22\u5f15\u5178(thesaurus)\u3002\u6536\u5f55\u5728PubMed\u4e2d\u7684\u671f\u520a\u6587\u732e\u90fd\u4f1a\u88ab\u8d4b\u4e88\u4e0d\u53ea\u4e00\u7ec4MeSH\u5173\u952e\u5b57\u3002\u901a\u8fc7\u8fd9\u4e9bMeSH\u5173\u952e\u5b57\u53ef\u4ee5\u6709\u6548\u805a\u96c6\u76f8\u5173\u4e3b\u9898\u4e4b\u671f\u520a\u6587\u732e\u3002\u901a\u8fc7MeSH\u53ef\u4ee5\u8fdb\u4e00\u6b65\u4e86\u89e3\u5173\u952e\u5b57\u4e4b\u95f4\u7684\u6811\u72b6\u5173\u8054\uff0c\u8fdb\u800c\u67e5\u627e\u66f4\u5e7f\u6cdb\u6216\u66f4\u7cbe\u786e\u4e4b\u6587\u732e\uff0c\u4ea6\u53ef\u521d\u6b65\u4e86\u89e3\u751f\u533b\u9886\u57df\u4e3b\u9898\u7684\u5168\u8c8c\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/nlmcatalog\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>NLM Catalog<\/strong><\/a><\/p>\n<p>NLM Catalog\u63d0\u4f9b\u7f8e\u56fd\u56fd\u5bb6\u533b\u5b66\u56fe\u4e66\u9986\u7684\u4e66\u76ee\u6570\u636e\u94fe\u63a5\uff0c\u5305\u542b\u671f\u520a\u3001\u56fe\u4e66\u3001\u89c6\u542c\u6570\u636e\u3001\u7535\u8111\u8f6f\u4ef6\u3001\u7535\u5b50\u8d44\u6e90\u3001\u4ee5\u53ca\u5176\u4ed6\u7c7b\u578b\u6570\u636e\u7b49\u3002\u4ea6\u63d0\u4f9b\u94fe\u63a5\u81f3\u7f8e\u56fd\u56fd\u5bb6\u533b\u5b66\u56fe\u4e66\u9986\u5728\u7ebf\u9986\u85cf\u76ee\u5f55LocatorPlus\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PubMed<\/strong><\/a><\/p>\n<p>PubMed\u6536\u5f55\u8d85\u8fc72800\u4e07\u7b14\u6765\u81eaMEDLINE\u7684\u751f\u533b\u9886\u57df\u6587\u732e\u3001\u751f\u547d\u79d1\u5b66\u671f\u520a\u3001\u4ee5\u53ca\u7535\u5b50\u4e66\u4e66\u76ee\u6570\u636e\u3002\u4e66\u76ee\u6570\u636e\u62a5\u542bPubMed Central\u4e0e\u51fa\u7248\u793e\u7f51\u7ad9\u7684\u5168\u6587\u94fe\u63a5(\u4f7f\u7528\u6743\u53d6\u51b3\u4e8e\u6240\u5c5e\u5355\u4f4d\u6216\u4e2a\u4eba\u662f\u5426\u6709\u8d2d\u4e70)\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PubMed Central<\/strong><\/a><\/p>\n<p>PubMed Central (PMC)\u662f\u7f8e\u56fd\u56fd\u5bb6\u533b\u5b66\u56fe\u4e66\u9986\u6240\u63d0\u4f9b\uff0c\u5173\u4e8e\u751f\u533b\u4e0e\u751f\u547d\u79d1\u5b66\u671f\u520a\u6587\u732e\u7684\u514d\u8d39\u7535\u5b50\u5168\u6587\u5bc4\u5b58\u7f51\u7ad9\u3002\u6b64\u5e73\u53f0\u63d0\u4f9b\u51fa\u7248\u793e\u4e0e\u4f5c\u8005\u4e2a\u4eba\u7533\u8bf7\u5b58\u653e\u5176\u8457\u4f5c\u4e4b\u7535\u5b50\u671f\u520a\u5168\u6587\uff0c\u5e76\u514d\u8d39\u63d0\u4f9b\u94fe\u63a5\u4f7f\u7528\u3002<\/p>\n<p><strong><a id=\"a3\"><\/a>Genes<\/strong><strong> (<\/strong><strong>\u57fa\u56e0\u76f8\u5173\u6570\u636e\u5e93)<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gene\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Gene<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u96c6\u6210\u5e7f\u5927\u8303\u56f4\u4e4b\u7269\u79cd\u4fe1\u606f\uff0c\u5355\u7b14\u6570\u636e\u53ef\u80fd\u5305\u542b\uff1a\u547d\u540d\u6cd5(nomenclature)\u3001\u53c2\u8003\u5e8f\u5217(RefSeqs)\u3001\u56fe\u8c31(maps)\u3001\u8def\u5f84(pathways)\u3001\u53d8\u5f02(variations)\u3001\u8868\u578b(phenotypes)\u4ee5\u53ca\u6765\u81ea\u5168\u4e16\u754c\u7684\u57fa\u56e0\u7ec4\u3001\u8868\u578b\u3001\u4e0e\u57fa\u56e0\u7279\u5f02\u94fe\u63a5\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gds\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>GEO DataSets<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u50a8\u5b58\u57fa\u56e0\u8868\u73b0\u578b\u7684\u6570\u636e\u96c6(DataSet)\uff0c\u4ee5\u53caGEO\u6570\u636e\u5e93\u4e2d\u7684\u539f\u59cbSeries\u53caPlatform\u7eaa\u5f55\u3002\u53ef\u8f93\u5165\u5173\u952e\u5b57\u67e5\u627e\u76f8\u5173\u7684\u5b9e\u9a8c\u3002DataSet\u7eaa\u5f55\u5305\u542b\u7fa4\u96c6\u5de5\u5177(cluster tools)\u4ee5\u53ca\u5dee\u5f02\u6027\u8868\u73b0\u67e5\u627e(differential expression queries)\u7b49\u989d\u5916\u8d44\u6e90\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/geoprofiles\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>GEO Profiles<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u50a8\u5b58GEO DataSet\u6570\u636e\u5e93\u4e2d\u7684\u5355\u4e00\u57fa\u56e0\u8868\u73b0\u8c31(individual gene expression profiles)\uff0c\u53ef\u4ee5\u7528\u57fa\u56e0\u6ce8\u8bb0(gene annotation)\u6216\u9884\u5148\u8fd0\u7b97\u4e4b\u8868\u73b0\u8c31\u7279\u5f81\u4e3a\u57fa\u7840\u641c\u7d22\u7279\u5b9a\u8868\u73b0\u8c31\u6570\u636e\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/homologene\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>HomoloGene<\/strong><\/a><\/p>\n<p>\u901a\u8fc7\u6765\u81ea\u5168\u4e16\u754c\u7684\u771f\u6838\u7269\u79cd\u57fa\u56e0\u96c6\uff0c\u672c\u6570\u636e\u5e93\u53ef\u67e5\u627e\u51fa\u5047\u8bbe\u7684\u540c\u6e90\u7fa4\u4f53\u6570\u636e\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/popset\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PopSet<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u63d0\u4f9b\u901a\u8fc7\u6f14\u5316\u76f8\u5173\u5b9e\u9a8c\u800c\u6536\u96c6\u7684DNA\u5e8f\u5217\u7ec4\uff0c\u8fd9\u4e9b\u5e8f\u5217\u7ec4\u53ef\u80fd\u6765\u81ea\u76f8\u540c\u7269\u79cd\u4e2d\u4e0d\u540c\u6210\u5458\uff0c\u4e5f\u53ef\u80fd\u6765\u81ea\u4e0d\u540c\u7269\u79cd\u7684\u6709\u673a\u7269\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/unigene\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>UniGene<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u53ef\u8fd0\u7b97\u51fa\u6765\u81ea\u76f8\u540c\u57fa\u56e0\u5ea7(locus)\u7684\u8f6c\u8bd1\u6587\u672c\uff0c\u4f9d\u7167\u5065\u5eb7\u72b6\u6001\u3001\u5e74\u9f84\u3001\u4ee5\u53ca\u7ec4\u7ec7\u6765\u5206\u6790\u8868\u73b0\u578b\uff0c\u4ee5\u53ca\u63d0\u4f9b\u76f8\u5173\u86cb\u767d\u8d28\u4ee5\u53ca\u76f8\u5173\u751f\u7269\u62f7\u8d1d\u6240\u9700\u8d44\u6e90(clone resources)\u3002<\/p>\n<p><strong><a id=\"a4\"><\/a>Genetics<\/strong> <strong>(<\/strong><strong>\u9057\u4f20\u5b66\u76f8\u5173\u6570\u636e\u5e93)<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>ClinVar<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u6536\u96c6\u9057\u4f20\u53d8\u5f02\u53ca\u5176\u4e0e\u4eba\u7c7b\u5065\u5eb7\u4e4b\u5173\u7cfb\u7684\u76f8\u5173\u4fe1\u606f\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gap\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>dbGaP<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u5168\u79f0\u4e3a\u201c\u57fa\u56e0\u578b\u4e0e\u8868\u73b0\u578b\u6570\u636e\u5e93\u201d(The database of Genotypes and Phenotypes, dbGaP)\uff0c\u4e3b\u8981\u81f4\u529b\u4e8e\u5178\u85cf\u4e0e\u4f20\u64ad\u4eba\u7c7b\u57fa\u56e0\u578b\u4e0e\u8868\u73b0\u578b\u4ea4\u4e92\u4f5c\u7528\u76f8\u5173\u89c2\u5bdf\u53ca\u7814\u7a76\u6240\u4ea7\u751f\u4e4b\u6570\u636e\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/snp\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>dbSNP<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u5305\u542b\u4eba\u7c7b\u5355\u4e00\u6838\u7518\u9178\u53d8\u5f02\u3001\u5fae\u536b\u661fDNA (microsatellites)\u3001\u5c0f\u89c4\u6a21\u6838\u7518\u9178\u7684\u63d2\u5165\/\u7f3a\u5931\u53ca\u5176\u9020\u6210\u7684\u5206\u5b50\u7ed3\u679c\u3001\u4ee5\u53ca\u7a81\u53d8(\u4e00\u822c\u4e0e\u4e34\u5e8a)\u7684\u57fa\u56e0\u7ec4\u4e0eRefSeq\u6bd4\u5bf9\u4fe1\u606f\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/dbvar\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>dbVar<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u4e3a\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7ed3\u6784\u53d8\u5f02\u76f8\u5173\u6570\u636e\u5e93\uff0c\u5305\u542bDNA\u7247\u6bb5\u7f3a\u5931\u3001\u63d2\u5165\u3001\u91cd\u590d\u3001\u91cd\u6392\u3001\u5012\u4f4d\u7b49\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/gtr\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>GTR<\/strong><\/a><\/p>\n<p>\u5168\u79f0\u4e3a\u9057\u4f20\u5b66\u6d4b\u8bd5\u6ce8\u518c\u6570\u636e\u5e93(The Genetic Testing Registry, GTR\u00ae)\uff0c\u63d0\u4f9b\u5168\u4e16\u754c\u7684\u81ea\u613f\u8005\u6ce8\u518c\u5176\u6240\u8fdb\u884c\u7684\u9057\u4f20\u5b66\u6d4b\u8bd5\u4fe1\u606f\uff0c\u8303\u56f4\u5305\u542b\u6d4b\u8bd5\u76ee\u7684\u3001\u65b9\u6cd5\u3001\u4fe1\u5ea6\u3001\u6d4b\u9a8c\u7684\u5b9e\u7528\u8bc1\u636e\u3001\u4ee5\u53ca\u5b9e\u9a8c\u5ba4\u7684\u8fde\u7edc\u4fe1\u606f\u7b49\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/medgen\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>MedGen<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u96c6\u6210\u4e86\u4eba\u7c7b\u533b\u7597\u9057\u4f20\u5b66\u76f8\u5173\u4fe1\u606f\uff0c\u4f8b\u5982\u67d0\u4e9b\u75be\u75c5\u72b6\u6001\u7279\u6027\u4e0e\u9057\u4f20\u4e4b\u5173\u7cfb\uff0c\u672c\u6570\u636e\u5e93\u4e5f\u63d0\u4f9b\u533b\u7597\u9057\u4f20\u5b66\u76f8\u5173\u6587\u732e\u94fe\u63a5\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/omim\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>OMIM<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u6c47\u6574\u4eba\u7c7b\u57fa\u56e0\u4e0e\u9057\u4f20\u8868\u73b0\u578b\uff0c\u514d\u8d39\u4e14\u6bcf\u5929\u66f4\u65b0\uff0c\u672c\u6570\u636e\u5e93\u7531\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u533b\u5b66\u9662McKusick-Nathans\u9057\u4f20\u533b\u5b66\u7814\u7a76\u6240\u8d1f\u8d23\u7ef4\u62a4\uff0c\u6240\u957f\u4e3aAda Hamosh\u535a\u58eb\uff0c\u6b64\u6570\u636e\u5e93\u7684\u5b98\u65b9\u4e3b\u9875\u4e3aomim.org.<\/p>\n<p>&nbsp;<\/p>\n<p><strong><a id=\"a5\"><\/a>Proteins<\/strong><strong> (<\/strong><strong>\u86cb\u767d\u8d28\u76f8\u5173\u6570\u636e\u5e93)<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/cdd\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Conserved Domains<\/strong><\/a><\/p>\n<p>\u5168\u79f0\u4e3a\u4fdd\u5b88\u7ed3\u6784\u57df\u6570\u636e\u5e93(Conserved Domain Database)\uff0c\u63d0\u4f9b\u86cb\u767d\u8d28\u4e2d\u529f\u80fd\u5355\u5143\u6ce8\u8bb0\u6240\u9700\u8d44\u6e90\uff0c\u6536\u5f55NCBI\u5229\u75283D\u7ed3\u6784\u4ea7\u751f\u7684\u7ed3\u6784\u57df\u6a21\u578b\uff0c\u5e2e\u52a9\u4e86\u89e3\u5e8f\u5217\/\u7ed3\u6784\/\u529f\u80fd\u7684\u5173\u8054\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/ipg\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Identical Protein Groups<\/strong><\/a><\/p>\n<p>\u5168\u79f0\u4e3a\u76f8\u4f3c\u86cb\u767d\u8d28\u7fa4\u7ec4\u6570\u636e\u5e93(Identical Protein Groups)\uff0c\u5728\u5355\u4e00\u6b3e\u76ee\u4e0b\u96c6\u6210\u4e0d\u540c\u6765\u6e90\uff0c\u5982GenBank\u3001RefSeq\u3001SwissProt\u3001\u4ee5\u53caPDB\u7b49\u7b49\u7684\u76f8\u4f3c\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\uff0c\u672c\u6570\u636e\u5e93\u8ba9\u7814\u7a76\u8005\u53ef\u83b7\u5f97\u66f4\u7cbe\u51c6\u7684\u7ed3\u679c\uff0c\u5e76\u5feb\u901f\u627e\u5230\u4e0e\u7814\u7a76\u4e3b\u9898\u76f8\u5173\u4e4b\u86cb\u767d\u8d28\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/protein\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Protein<\/strong><\/a><\/p>\n<p>\u6536\u5f55\u6765\u81eaGenBank\u3001RefSeq\u3001TPA\u3001SwissProt\u3001PIR\u3001PRF\u3001\u53caPDB\u7b49\u6570\u636e\u5e93\u7684\u86cb\u767d\u8d28\u5e8f\u5217\u6570\u636e\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/proteinclusters\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Protein Clusters<\/strong><\/a><\/p>\n<p>\u6536\u5f55\u76f8\u4f3c\u86cb\u767d\u8d28\u5e8f\u5217\u7fa4\u96c6\uff0c\u5305\u542b\u81ea\u5b8c\u6574\u6ce8\u8bb0\u57fa\u56e0\u7ec4\u3001\u7ec6\u80de\u5668\u3001\u6216\u8d28\u4f53\u4e2d\u622a\u53d6\u4e4b\u86cb\u767d\u8d28\uff0c\u76ee\u524d\u9650\u5236\u5728\u53e4\u7ec6\u83cc\u3001\u7ec6\u83cc\u3001\u690d\u7269\u3001\u771f\u83cc\u7c7b\u3001\u539f\u751f\u751f\u7269\u7b49\u7c7b\u522b\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/sparcle\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Sparcle<\/strong><\/a><\/p>\n<p>\u4f9d\u7167\u7ed3\u6784\u57df\u67b6\u6784(domain architecture)\u6240\u505a\u7684\u86cb\u767d\u8d28\u529f\u80fd\u5206\u7c7b\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/structure\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Structure<\/strong><\/a><\/p>\n<p>\u6536\u5f55\u5206\u5b50\u751f\u7269\u7ed3\u6784\u5b9e\u9a8c\u4ea7\u51fa\u4e4b3D\u7ed3\u6784\uff0c\u53ef\u63d0\u4f9b\u751f\u7269\u529f\u80fd\u4ee5\u53ca\u5927\u5206\u5b50\u6f14\u5316\u5386\u53f2\u7b49\u4e30\u5bcc\u4fe1\u606f\uff0c\u4e5f\u53ef\u7528\u6765\u9a8c\u8bc1\u5e8f\u5217-\u7ed3\u6784-\u529f\u80fd\u7684\u5173\u7cfb\u3001\u4ea4\u4e92\u4f5c\u7528\u3001\u6d3b\u6027\u4f4d\u70b9(active sites)\u7b49\u3002<\/p>\n<p><strong><a id=\"a6\"><\/a>Genomes<\/strong><strong>(<\/strong><strong>\u57fa\u56e0\u7ec4\u76f8\u5173\u6570\u636e\u5e93)<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/assembly\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Assembly<\/strong><\/a><\/p>\n<p>\u63d0\u4f9b\u57fa\u56e0\u7ec4\u7ec4\u88c5\u4fe1\u606f\uff0c\u5305\u542b\u5df2\u7ec4\u88c5\u4e4b\u57fa\u56e0\u7ec4\u3001\u7ec4\u88c5\u540d\u79f0\u3001\u7edf\u8ba1\u62a5\u8868\u3001\u4ee5\u53ca\u57fa\u56e0\u7ec4\u5e8f\u5217\u6570\u636e\u4e4b\u94fe\u63a5\u7b49\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/biocollections\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>BioCollections<\/strong><\/a><\/p>\n<p>\u535a\u7269\u9986\u3001\u6807\u672c\u9986\u4ee5\u53ca\u5176\u4ed6\u751f\u7269\u5bc4\u5b58\u5355\u4f4d\u4e4b\u6536\u85cf\u6e05\u5355(\u4ee5Collection\u4e3a\u5355\u4f4d)\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>BioProject<\/strong><\/a><\/p>\n<p>\u63d0\u4f9b\u6570\u636e\u7ed9NCBI\u4e4b\u751f\u7269\u8ba1\u5212\u5c0f\u7ec4\u6e05\u5355\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/biosample\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>BioSample<\/strong><\/a><\/p>\n<p>\u63d0\u4f9b\u4e0a\u4f20\u81f3NCBI\u4e4b\u751f\u7269\u8d44\u6e90\u4e4b\u63cf\u8ff0\u4e0e\u540e\u8bbe\u6570\u636e\uff0c\u539f\u59cb\u6570\u636e\u5b58\u653e\u4e8eSRA, GEO, dbGaP, GenBank, EST, GSS, WGS\u7b49\u6570\u636e\u5e93\uff0c\u4e14\u53ef\u94fe\u63a5\u81f3BioProject\u6570\u636e\u5e93\u3002\u8fd9\u4e9b\u63cf\u8ff0\u4e0e\u540e\u8bbe\u6570\u636e\u5185\u5bb9\u662f\u7531\u751f\u7269\u8d44\u6e90\u4e0a\u4f20\u8005\u63d0\u4f9b\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/nuccore\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Nucleotide<\/strong><\/a><\/p>\n<p>\u63d0\u4f9b\u6765\u81ea\u5168\u4e16\u754c\u7814\u7a76\u8005\u6240\u4ea7\u51fa\u7684DNA\u4e0eRNA\u5e8f\u5217\u6570\u636e\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/probe\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Probe<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u662f\u7528\u6765\u4ece\u4e8b\u5404\u79cd\u751f\u7269\u533b\u5b66\u7814\u7a76\u5e94\u7528\u4e4b\u6838\u9178\u8bd5\u5242\u7684\u516c\u5f00\u6ce8\u518c\u5e73\u53f0\uff0c\u6536\u5f55\u4fe1\u606f\u5305\u542b\u3001\u63a2\u6d4b\u6548\u5ea6\u3001\u4ee5\u53ca\u7ecf\u8ba1\u7b97\u7684\u5e8f\u5217\u76f8\u4f3c\u6027\u7b49\u4fe1\u606f\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/sra\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>SRA<\/strong><\/a><\/p>\n<p>\u6536\u96c6\u901a\u8fc7\u65b0\u4e00\u4ee3\u5b9a\u5e8f\u5de5\u5177\u53d6\u5f97\u4e4b\u57fa\u56e0\u5e8f\u5217\u6570\u636e\uff0c\u4f8b\u5982Roche 454 GS System\u00ae, Illumina Genome Analyzer\u00ae, Applied Biosystems SOLiD System\u00ae, Helicos Heliscope\u00ae, Complete Genomics\u00ae, and Pacific Biosciences SMRT\u00ae\u7b49\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/taxonomy\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Taxonomy<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u53ef\u67e5\u5f97\u516c\u5f00\u5e8f\u5217\u6570\u636e\u5e93\u4e2d\u6709\u673a\u7269\u7684\u5206\u7c7b\u4e0e\u547d\u540d\u6cd5\u3002\u76ee\u524d\u5927\u7ea6\u6536\u5f55\u5730\u7403\u4e0a10%\u7684\u5df2\u77e5\u7269\u79cd\u4fe1\u606f\u3002<\/p>\n<p><strong><a id=\"a7\"><\/a>Chemicals<\/strong><strong> (<\/strong><strong>\u5316\u5b66\u76f8\u5173\u6570\u636e\u5e93)<\/strong><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/biosystems\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>BioSystems<\/strong><\/a><\/p>\n<p>\u63d0\u4f9b\u94fe\u63a5\u81f3\u5404\u79cd\u751f\u7269\u7cfb\u7edf\uff0c\u5305\u542b\u5176\u7ec4\u6210\u7684\u57fa\u56e0\u3001\u86cb\u767d\u8d28\u3001\u4ee5\u53ca\u5c0f\u5206\u5b50\u4fe1\u606f(\u542b\u4f20\u5bfc\u8def\u5f84\u7b49)\uff0c\u53e6\u5916\u4e5f\u5305\u542b\u6587\u732e\u6570\u636e\uff0c\u4ee5\u53caEntrez\u4e0a\u7684\u76f8\u5173\u6570\u636e\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pcassay\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PubChem BioAssay<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u5305\u542bPubChem Subtance\u4e2d\u5bf9\u4e8e\u5316\u5b66\u7269\u8d28\u7684\u751f\u7269\u6d3b\u52a8\u76d1\u63a7\u4fe1\u606f\uff0c\u672c\u6570\u636e\u5e93\u9488\u5bf9\u6bcf\u4e2a\u751f\u7269\u68c0\u5b9a\u6cd5(bioassay)\u63d0\u4f9b\u53ef\u641c\u7d22\u7684\u63cf\u8ff0\uff0c\u5305\u542b\u5404\u79cd\u60c5\u51b5\u53ca\u7279\u5b9a\u76d1\u63a7\u7a0b\u5e8f\u4e4b\u8f93\u51fa(readouts)\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pccompound\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PubChem Compound<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u63d0\u4f9b\u6709\u6548\u7684\u63cf\u8ff0\u6027\u4fe1\u606f\u7528\u4ee5\u63cf\u8ff0PubChem Substance\u6570\u636e\u5e93\u4e2d\u7684\u7269\u8d28\u3002\u50a8\u5b58\u4e8e\u672c\u6570\u636e\u5e93\u4e2d\u7684\u5316\u5b66\u7ed3\u6784\u90fd\u88ab\u6309\u7167\u76f8\u4f3c\u6027\u4e0e\u540d\u79f0\u805a\u96c6\u8d77\u6765\uff0c\u5e76\u5145\u5206\u4e92\u76f8\u53c2\u7167\u3002<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pcsubstance\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>PubChem Substance<\/strong><\/a><\/p>\n<p>\u672c\u6570\u636e\u5e93\u6536\u5f55\u6837\u672c\u7684\u63cf\u8ff0\uff0c\u5e76\u63d0\u4f9b\u7684\u94fe\u63a5\u81f3PubChem BioAssay\u6570\u636e\u5e93\u7684\u751f\u7269\u76d1\u63a7\u7ed3\u679c\u4fe1\u606f\uff0c\u5982\u679c\u8fd9\u4e9b\u5316\u5b66\u5185\u5bb9\u5305\u542b\u4e86\u5df2\u77e5\u5316\u5b66\u7269\u8d28\uff0c\u5219\u4f1a\u63d0\u4f9b\u94fe\u63a5\u81f3PubChem Compound\u6570\u636e\u5e93\u3002<\/p>\n<p>\u53c2\u8003\u6570\u636e\uff1a<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/Web\/Search\/entrezfs.html\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.ncbi.nlm.nih.gov\/Web\/Search\/entrezfs.html<\/a><\/p>\n<p>post by: Wen-Chi Huang<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Entrez\u5206\u5b50\u5e8f\u5217\u6570\u636e\u5e93\u7cfb\u7edf(Entrez Molecular Sequence Database System)\u662f\u4e00\u4e2a\u96c6\u6210\u578b\u7684\u68c0\u7d22\u754c\u9762\uff0c\u7f51\u5740\u4e3a\uff1ahttps:\/\/www.ncbi.nlm.nih.gov\/search\/\uff0c\u7531\u7f8e\u56fd\u56fd\u5bb6\u751f\u533b\u4fe1\u606f\u4e2d\u5fc3(National Center for Biotechnology Information, NCBI)\u5efa\u7f6e<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[865,866],"class_list":["post-2337","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-entrez","tag-ncbi"],"_links":{"self":[{"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/posts\/2337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/comments?post=2337"}],"version-history":[{"count":2,"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/posts\/2337\/revisions"}],"predecessor-version":[{"id":3213,"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/posts\/2337\/revisions\/3213"}],"wp:attachment":[{"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/media?parent=2337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/categories?post=2337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.jiansuoke.com\/post\/wp-json\/wp\/v2\/tags?post=2337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}